Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)

Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM

Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDermTM skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide (TNPs), and silver (AgNPs) for a defined time...

In Vitro and In Vivo Toxicity Studies of Engineered Nanoparticles

Evaluation of a New Alternative to Primary Draize Skin Irritation Testing Using the EpiDermTM Skin Model

Correspondence : Michiru Genno, Technical Research Laboratory, Kurabo Industries Ltd., 14-5 Shimokidacho Neyagawa-shi, Osaka 572-0823, Japan. Tel.: +(81) 720 23 8800, Fax: +(81) 720 23 7906, E-mail: [email protected]

In vitro toxicity testing of nanoparticles in 3D cell culture.

Common 2D cell cultures do not adequately represent the functions of 3D tissues that have extensive cell-cell and cell-matrix interactions, as well as markedly different diffusion/transport conditions. Hence, testing cytotoxicity in 2D cultures may not accurately reflect the actual toxicity of nanoparticles (NPs) and other nanostructures in the body. To obtain more adequate and detailed informa...

assessment of the efficiency of s.p.g.c refineries using network dea

data envelopment analysis (dea) is a powerful tool for measuring relative efficiency of organizational units referred to as decision making units (dmus). in most cases dmus have network structures with internal linking activities. traditional dea models, however, consider dmus as black boxes with no regard to their linking activities and therefore do not provide decision makers with the reasons...